| Patent Number |
CA2516581 A1 2004-09-02 |
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Attenuated strains of vibrio cholerae and lyophilised vaccines containing same
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The present invention discloses new live attenuated strains for oral immunization against cholera that are provided in freeze dried formulations for long term storage and administration to humans.These strains combine the two most important properties of live attenuated cholera vaccine candidates.One such property is being well tolerated by people ingesting them.This was achieved by virtue of mutations already described in the art.The second property is having enhanced environmental safety due to the absence of VGJ¦ DNA in their genomes and also due to null mutations in the mshA gene or other spontaneous mutations conducive to the lack of MSHA type IV fimbria on the bacterial surface.This was done envisioning that VGJ¦ is a filamentous phage able to recombine with CTX¦ and disseminate the cholera toxin genes.This VGJ¦ phage as well as the VGJ¦-CTX¦ recombinants uses the MSHA fibers as receptor.Being devoid of MSHA fimbria the vaccine candidates are protected from acquiring CTX¦ from the recombinant hybrid VGJ¦-CTX¦.Being devoid of VGJ¦, the vaccine candidates are impaired in the dissemination of CTX¦, via VGJ¦.
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©Questel
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| FamPat family |
| Publication Number |
Type |
Publi.Date |
Links |
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EP1614426 |
A1 |
2006-01-11 |
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STG: |
(A1) Application published with search report |
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AP: |
2004EP-0712469 |
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EP1614426 |
B1 |
2008-12-17 |
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STG: |
(B1) Patent specification |
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AP: |
2004EP-0712469 |
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US20070071775 |
A1 |
2007-03-29 |
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STG: |
(A1) Application published |
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AP: |
2004US-10546410 |
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US7592171 |
B2 |
2009-09-22 |
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STG: |
(B2) Granted patent as second publication |
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AP: |
2004US-10546410 |
| PCT |
WO2004/073736 |
A1 |
2004-09-02 |
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STG: |
(A1) Published application with search report |
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AP: |
2004WO-CU00002 |
| PCT |
WO2004/073736 |
A8 |
2005-11-17 |
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STG: |
(A8) Modified first page |
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AP: |
2004WO-CU00002 |
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DE602004018478 |
D1 |
2009-01-29 |
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STG: |
(D1) Grant (no unexamined application published) patent law 81 |
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AP: |
2004DE-60018478 |
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JP2006518196 |
A |
2006-08-10 |
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STG: |
(A) Published application |
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AP: |
2006JP-0501454 |
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JP4495143 |
B2 |
2010-06-30 |
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STG: |
(B2) Published granted patent (Second level) from 01-03-1996 onwards (Published examined patent application (Second level) 1971-1996) |
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AP: |
2006JP-0501454 |
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RU2005125793 |
A |
2006-05-27 |
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STG: |
(A) Application for invention |
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AP: |
2005RU-0125793 |
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RU2316587 |
C2 |
2008-02-10 |
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STG: |
(C2) Patent for invention ( 2nd publ.) |
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AP: |
2005RU-0125793 |
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ECSP055971 |
A |
2006-01-16 |
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STG: |
(A) Patent application |
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AP: |
2005EC-0005971 |
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MXPA05008774 |
A |
2006-02-22 |
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STG: |
(A) Patent application |
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AP: |
2005MX-PA08774 |
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BRPI0407668 |
A |
2006-03-01 |
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STG: |
(A) Published application |
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AP: |
2004BR-0007668 |
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CA2516581 |
A1 |
2004-09-02 |
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STG: |
(A1) Application laid open |
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AP: |
2004CA-2516581 |
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CA2516581 |
C |
2012-05-15 |
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STG: |
(C) Patent (second level) |
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AP: |
2004CA-2516581 |
| ARIPO |
AP2005003378 |
A0 |
2005-09-30 |
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STG: |
(A0) Application filed, as announced in the Gazette published by this office |
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AP: |
2005AP-0003378 |
| ARIPO |
AP200503378 |
D0 |
2005-09-30 |
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STG: |
(D0) Patent application filed |
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AP: |
2005AP-0003378 |
| ARIPO |
AP1724 |
A |
2007-02-23 |
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STG: |
(A) Patent |
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AP: |
2005AP-0003378 |
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VN12100 |
A |
2006-03-26 |
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STG: |
(A) Publication Number |
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AP: |
2005VN-1001305 |
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VN0013780 |
B |
2015-04-27 |
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STG: |
(B) Granted patent |
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AP: |
2005VN-1001305 |
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CN1780640 |
A |
2006-05-31 |
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STG: |
(A) Published application |
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AP: |
2004CN-80010101 |
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CN100569286 |
C |
2009-12-16 |
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STG: |
(C) Granted patent for invention |
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AP: |
2004CN-80010101 |
| OAPI |
OA13033 |
A |
2006-11-10 |
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STG: |
(A) Patent of invention |
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AP: |
2005OA-1000234 |
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IN3727/DELNP/2005 |
A |
2007-08-24 |
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STG: |
(A) Application laid open |
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AP: |
2005IN-DN03727 |
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IN233428 |
B |
2009-03-27 |
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STG: |
(B) Patent |
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AP: |
2005IN-DN03727 |
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ATE417625 |
T1 |
2009-01-15 |
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STG: |
(T1) Translation of an European patent specification |
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AP: |
2004AT-0712469T |
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DK1614426 |
T3 |
2009-04-06 |
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STG: |
(T3) Translation of EP patent |
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AP: |
2004DK-0712469 |
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ES2319527 |
T3 |
2009-05-08 |
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STG: |
(T3) Translation of granted European patent (former B3) |
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AP: |
2004ES-0712469T |
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| First Date of Grant |
2008-12-17 |
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2009-09-22 |
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2009-01-29 |
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2010-06-30 |
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2008-02-10 |
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2006-11-10 |
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2007-02-23 |
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2009-03-27 |
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2009-01-15 |
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2009-04-06 |
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2009-05-08 |
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2009-12-16 |
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2012-05-15 |
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2015-04-27 |
| Inventor |
CAMPOS GOMEZ JAVIER
MOREIRA HERNANDEZ TOMAS MARCELINO
RODRIGUEZ GONZALEZ BORIS LUIS
MARRERO DOMINGUEZ KAREN
MARTINEZ GUTIERREZ ERIEL
LEDON PEREZ TALENA YAMILE
SILVA LARRANAGA YUSSUAN
SUZARTE PORTAL EDITH
DELGADO RODRIGUEZ HERMINIA DE
URRA VILLAVICENCIO CARIDAD
FANDO CALZADA RAFAEL ALFREDO |
| All applicant/assignee |
Centro Nacional De Investigaciones Cientificas (CNIC) ([CU])
Centro Nacional De Investigaciones Cientificas (CNIC) ([CU]) |
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CAMPOS GOMEZ JAVIER
MOREIRA HERMANDEZ TOMAS MARCEL
RODRIGUEZ GONZALEZ BORIS L
MARRERO DOMINGUEZ KAREN
MARTINEZ GUTIERREZ ERIEL
LEDON PEREZ TALENA Y
SILVA LARRANAGA YUSSUAN
SUZARTE PORTAL EDITH
DELGADO RODRIGUEZ HERMINIA D L
URRA VILLAVICENCIO CARIDAD
FANDO CALZADA RAFAEL A
Centro Nacional de Investigaciones Cientificas (CNIC) ([CU]) |
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CENTRO NACIONAL DE INVESTIGACIONES CIENTIFICAS (CNIC) ([CU])
CENTRO NACIONAL DE INVESTIGACIONES CIENTIFICAS (CNIC) |
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CENTRO NACIONAL DE INVESTIGACIONES CIENTIFICAS (CNIC) |
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National Institute Centro de-gating Ventura Bastions Fikasu system entity (Seeneise)
Centro National de Ingestigations Cientificus (Senee Sae) Cuba, Havana 1 2 1 0 0, Playa, Qubanacan, Avei. 2 5 ENE. 1 5 2 0 2 Aeseku. Ah 1 5 8, Playa, Qubanacan, Avee. 2 5 ENE. 1 5 2 0 2 Aeseku. A 1 5 8 |
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NATsIONAL'NYJ TsENTR NAUChNYKh ISSLEDOVANIJ (SNIS) (CU)
NATsIONAL'NYJ TsENTR NAUChNYKh ISSLEDOVANIJ (SNIS) (CU) |
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CENTRO NATIONAL DE INVESTIGACIONES CIENTIFICAS |
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CENTRO NACIONAL DE INVESTIGACIONES CIENTIFICAS (CNIC)
CENTRO NACIONAL DE INVESTIGACIONES CIENTIFICAS (CNIC) |
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CENTRO NACIONAL DE INVESTIGACIONES CIENTIFICAS (CNIC) ([CU])
CENTRO NACIONAL DE INVESTIGACIONES CIENTIFICAS (CNIC) |
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CENTRO NACIONAL DE INVESTIGACIONES CIENTIFICAS ( CINC ) |
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CENTRO NACIONAL DE INVESTIGACIONES CIENTIFICAS (CNIC) |
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CENTRO NACIONAL DE INVESTIGACIONES CIENTIFICAS (CNIC), |
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CENTRO NACIONAL DE INVESTIGACIONES CIENTIFICAS (CNIC) |
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CENTRO NACIONAL DE INVESTIGACIONES CIENTIFICAS (CNIC) |
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CENTRO NACIONAL DE INVESTIGACIONES CIENTIFICAS (CNIC) |
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CT NAC DE INVESTIGACIONES CIEN ([CU])
CT NAC DE INVESTIGACIONES CIEN ([CU]) |
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CENTRO NACIONAL DE INVESTIGACIONES CIENTIFICAS (CNIC) ([CU])
CENTRO NACIONAL DE INVESTIGACIONES CIENTIFICAS (CNIC) ([CU]) |
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CENTRO NACIONAL DE INVESTIGACIONES CIENTIFICAS (CNIC) ([CU])
CENTRO NACIONAL DE INVESTIGACIONES CIENTIFICAS (CNIC) ([CU]) |
| Priority Details |
2003CU-0000039 2003-02-202003CU-0000084 2003-04-172004WO-CU00002 2004-02-19 |
| Designated States |
Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PT RO SE SI SK TR |
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National States: AE AG AL AM AT AU AZ BA BB BG BR BW BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE EG ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NA NI NO NZ OM PG PH PL PT RO RU SC SD SE SG SK SL SY TJ TM TN TR TT TZ UA UG US UZ VC VN YU ZA ZM ZW
ARIPO: BW GH GM KE LS MW MZ SD SL SZ TZ UG ZM ZW
EAPO: AM AZ BY KG KZ MD RU TJ TM
EPO: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LU MC NL PT RO SE SI SK TR
OAPI: BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG |
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©Questel
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