| Patent Number |
ZA200610588 B 2008-06-25 |
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Combinations of substituted 1-phenyl-1,5-dihydro-pyrido- [3,2-b] indol-2-ones and other hiv inhibitors
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The present invention concerns combinations comprising a compound of formula (I); the N-oxides, salts, stereoisomeric forms, racemic mixtures, prodrugs, esters or metabolites thereof, wherein n is 1, 2 or 3; R1 is H, CN, halo, aminoC(=O), C(=O)OH, C1-4alkyloxyC(=O), C1-4 alkylC(=O), mono- or di(C1-4alkyl)aminoC(=O), arylaminoC(=O), N-(aryl)-N-(C1-4 alkyl)aminoC(=O), methanimidamidyl, N-hydroxy-methanimidamidyl, mono- or di(C1-4alkyl)methanimidamidyl, Het1 or Het2; R2 is H, C1-10alkyl, C2-10alkenyl, C3-7cycloalkyl, wherein said C1-10alkyl, C2-10alkenyl and C3-7 cycloalkyl may be optionally substituted; R3 is nitro, cyano, amino, halo, hydroxy, C1-4alkyloxy, hydroxyC(=O), aminoC(=O), C1-4alkyloxyC(=O), mono- or di(C1-4alkyl)aminoC(=O), C1-4alkylC(=O), methanimidamidyl, mono- or di(C1-4alkyl)methanimidamidyl, N-hydroxy-methanimidamidyl or Het1; and another HIV inhibitor.The invention also concerns products comprising a compound of formula (I) and another HIV inhibitor, as a combined preparation for simultaneous, separate or sequential use in treatment of retroviral infections such as HIV infection, in particular, in the treatment of infections with multi-drug resistant retroviruses.
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©Questel
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| FamPat family |
| Publication Number |
Type |
Publi.Date |
Links |
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EP1750708 |
A1 |
2007-02-14 |
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STG: |
(A1) Application published with search report |
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AP: |
2005EP-0747916 |
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US20070249655 |
A1 |
2007-10-25 |
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STG: |
(A1) Application published |
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AP: |
2005US-11569111 |
| PCT |
WO2005/110411 |
A1 |
2005-11-24 |
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STG: |
(A1) Published application with search report |
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AP: |
2005WO-EP52266 |
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JP2007538053 |
A |
2007-12-27 |
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STG: |
(A) Published application |
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AP: |
2007JP-0517256 |
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AU2005244449 |
A1 |
2005-11-24 |
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STG: |
(A1) Open to public inspection |
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AP: |
2005AU-0244449 |
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CA2563601 |
A1 |
2005-11-24 |
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STG: |
(A1) Application laid open |
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AP: |
2005CA-2563601 |
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TW200612946 |
A |
2006-05-01 |
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STG: |
(A) Laid open application for patent or patent of addition |
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AP: |
2005TW-0116035 |
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AR048962 |
A1 |
2006-06-14 |
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STG: |
(A1) Independent patent application |
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AP: |
2005AR-0102016 |
| ARIPO |
AP2006003794 |
A0 |
2006-10-31 |
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STG: |
(A0) Application filed, as announced in the Gazette published by this office |
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AP: |
2006AP-0003794 |
| ARIPO |
AP200603794 |
D0 |
2006-10-31 |
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STG: |
(D0) Patent application filed |
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AP: |
2006AP-0003794 |
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KR10-2007-0011588 |
A |
2007-01-24 |
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STG: |
(A) Published application |
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AP: |
2006KR-7025921 |
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MXPA06013316 |
A |
2007-02-02 |
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STG: |
(A) Patent application |
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AP: |
2006MX-PA13316 |
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CN1953751 |
A |
2007-04-25 |
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STG: |
(A) Published application |
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AP: |
2005CN-80015688 |
| EAPO |
EA200602136 |
A1 |
2007-04-27 |
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STG: |
(A1) Public. of applic. with search report |
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AP: |
2006EA-0002136 |
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IN6106/DELNP/2006 |
A |
2007-08-31 |
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STG: |
(A) Application laid open |
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AP: |
2006IN-DN06106 |
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BRPI0511144 |
A |
2007-11-27 |
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STG: |
(A) Published application |
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AP: |
2005BR-0011144 |
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ZA200610588 |
B |
2008-06-25 |
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STG: |
(B) Granted Patent |
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AP: |
2006ZA-0010588 |
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| First Date of Grant |
2008-06-25 |
| Inventor |
KESTELEYN BART RUDOLF ROMANIE
VAN DE VREKEN WIM
KINDERMANS NATALIE MARIA FRANC
CANARD MAXIME FRANCIS JEAN-MAR
HERTOGS KURT
BETTENS EVA
DE VROEY VERONIQUE CORINE PAUL
JOCHMANS DIRK EDWARD DESIRE
WIGERINCK PIET TOM BERT PAUL
WANG JING
TAHRI ABDELLAH
SURLERAUX DOMINIQUE LOUIS NEST |
| All applicant/assignee |
Tibotec Pharmaceuticals Ltd. ([IE]) |
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KESTELEYN BART R R
VAN DE VREKEN WIM
KINDERMANS NATALIE M F
CANARD MAXIME FRANCIS J G
HERTOGS KURT
BETTENS EVA
DE VROEY VERONIQUE C P
JOCHMANS DIRK E D
WIGERINCK PIET T B
TAHRI ABDELLAH
WANG JING
SURLERAUX DOMINIQUE LOUIS N G |
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TIBOTEC PHARMACEUTICALS LTD. ([IE]) |
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TIBOTEC PHARMACEUTICALS LTD |
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JANSSEN R&D IRELAND |
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TIBOTEC PHARMACEUTICALS LTD |
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TIBOTEC PHARMACEUTICALS LTD. |
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TIBOTEC PHARMACEUTICALS LTD ([IE]) |
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TIBOTEC PHARMACEUTICALS LTD. |
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TIBOTEC PHARMACEUTICALS LTD. ([IE]) |
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TIBOTEC PHARMACEUTICALS LTD. |
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TIBOTEC PHARMACEUTICALS LTD. |
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TIBOTEC PHARMACEUTICALS LTD. |
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TIBOTEC PHARMACEUTICALS LTD. |
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TIBOTEC PHARMACEUTICALS LTD. |
| Priority Details |
2004EP-0102173 2004-05-172004US-10102173 2004-05-172005EP-0747916 2005-05-172005WO-EP52266 2005-05-17 |
| Designated States |
Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU MC NL PL PT RO SE SI SK TR
Extension States: AL BA HR LV MK YU |
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National States: AE AG AL AM AT AU AZ BA BB BG BR BW BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE EG ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KM KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NA NG NI NO NZ OM PG PH PL PT RO RU SC SD SE SG SK SL SM SY TJ TM TN TR TT TZ UA UG US UZ VC VN YU ZA ZM ZW
ARIPO: BW GH GM KE LS MW MZ NA SD SL SZ TZ UG ZM ZW
EAPO: AM AZ BY KG KZ MD RU TJ TM
EPO: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LT LU MC NL PL PT RO SE SI SK TR
OAPI: BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG |
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©Questel
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