Patent Number US8217149 B2 2012-07-10
 
Anti-pd-l1 antibodies and their use to enhance t-cell function
The present application relates to anti-PD-L1 antibodies, nucleic acid encoding the same, therapeutic compositions thereof, and their use enhance T-cell function to upregulate cell-mediated immune responses and for the treatment of T cell dysfunctional disorders, including infection ( e.g ., acute and chronic) and tumor immunity.
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First Date of Grant 2017-04-12
2024-01-31
2025-03-05
2012-07-10
2018-03-20
2019-01-11
2015-03-11
2017-08-09
2019-05-08
2023-08-23
2017-11-17
2013-06-26
2016-07-07
2017-03-31
2017-11-30
2018-02-15
2018-02-21
2018-06-25
2020-04-16
2022-01-06
2023-11-16
2024-02-29
2024-04-12
2025-05-09
2025-05-21
2012-01-02
2013-12-21
2014-12-31
2015-07-27
2016-10-05
2017-04-30
2017-06-12
2017-06-26
2017-07-31
2017-08-01
2017-08-25
2017-09-22
2017-09-27
2017-09-29
2017-11-21
2018-01-10
2018-02-01
2018-04-04
2018-05-25
2018-09-21
2019-03-31
2019-05-10
2020-03-01
2020-10-29
2020-11-30
2021-06-01
2021-07-20
2021-08-17
2024-03-12
2024-03-22
2024-04-26
2024-04-30
2024-05-13
2024-06-27
2024-04-15
2025-04-24
2025-04-25
2025-04-28
2025-05-09
2025-05-12
Inventor IRVING BRYAN
CHEUNG JEANNE
CHIU HENRY
LEHAR SOPHIE M
MAECKER HEATHER
MARIATHASAN SANJEEV
WU YAN
All applicant/assignee Genentech, Inc. ([US])
F.Hoffmann-La Roche AG ([CH])
F. Hoffmann-La Roche AG ([CH])
F. Hoffmann-La Roche AG ([CH])
F. Hoffmann-La Roche AG ([CH])
F. Hoffmann-La Roche AG ([CH])
F. Hoffmann-La Roche AG ([CH])
F. Hoffmann-La Roche AG ([CH])
F. Hoffmann-La Roche AG ([CH])
F. Hoffmann-La Roche AG ([CH])
F. Hoffmann-La Roche AG ([CH])
F. Hoffmann-La Roche AG ([CH])
F. Hoffmann-La Roche AG ([CH])
Genentech, Inc. ([US])
Genentech, Inc. ([US])
Genentech, Inc. ([US])
Genentech, Inc. ([US])
Genentech, Inc. ([US])
Genentech, Inc. ([US])
GENENTECH, INC. ([US])
GENENTECH, INC. ([US])
Genentech, Inc. ([US])
Genentech, Inc. ([US])
Genentech, Inc. ([US])
Genentech, Inc. ([US])
Genentech, Inc. ([US])
GENENTECH, INC. ([US])
HOFFMANN LA ROCHE ([CH])
HOFFMANN LA ROCHE ([CH])
GENENTECH INC
GENENTECH INC
GENENTECH INC
GENENTECH INC
GENENTECH INC
GENENTECH INC
GENENTECH INC
GENENTECH INC
GENENTECH INC
GENENTECH INC
GENENTECH INC. ([US])
GENENTECH INC. ([US])
GENENTECH INC. ([US])
GENENTECH, INC.
GENENTECH INC
GENENTECH, INC.
F HOFFMANN-LA ROCHE AG
GENENTECH, INC.
GENENTECH, INC.
GENENTECH ([US])
GENENTECH INC.
GENENTECH, INC. ([US])
GENENTECH, INC. ([US])
GENENTECH, INC.
GENENTECH, INC.
F. Hoffmann-La Roche AG
F. Hoffmann-La Roche AG
F HOFFMANN-LA ROCHE AG ([CH])
F HOFFMANN LA ROCHE AG
F HOFFMANN-LA ROCHE AG
GENENTECH, INC.
GENENTECH, INC.
GENENTECH, INC.
F HOFFMANN-LA ROCHE AG
GENENTECH, INC.
GENENTECH, INC.
GENENTECH INC
GENENTECH, INC.
GENENTECH, INC. ([US])
GENENTECH INC
F Hoffmann-La Roche AG ([CH])
F Hoffmann-La Roche AG ([CH])
F. HOFFMANN-LA ROCHE AG
F. Hoffmann-La Roche AG
GENENTECH, INC. ([US])
GENENTECH, INC.
GENENTECH, INC.
GENENTECH INC
GENENTECH INC*
GENENTECH, INC.
GENENTECH, INC.
GENENTECH, INC.
GENENTECH, INC.
F.HOFFMANN LA ROCHE AG
GENENTECH INC.
GENENTECH, INC.
GENENTECH, INC.
GENENTECH, INC.
HOFFMANN-LA ROCHE
HOFFMANN-LA ROCHE
GENENTECH, INC.
F.HOFFMANN LA ROCHE AG
GENENTECH INC* ([US])
GENENTECH INC ([US])
GENENTECH , INC
GENENTECH, INC.
GENENTECH, INC. ([US])
HOFFMANN LA ROCHE ([CH])
HOFFMANN LA ROCHE ([CH])
F. Hoffmann-La Roche AG
HOFFMANN LA ROCHE ([CH])
F. Hoffmann-La Roche AG
HOFFMANN LA ROCHE ([CH])
GENENTECH INC ([US])
GENENTECH INC ([US])
F. Hoffmann - La Roche AG
GENENTECH, INC.
GENENTECH, INC.
F.HOFFMANN-LA ROCHE AG
GENENTECH, INC.
GENENTECH, INC.
GENENTECH, INC.
HOFFMANN LA ROCHE ([CH])
F. HOFFMANN-LA ROCHE AG
HOFFMANN LA ROCHE ([CH])
F. Hoffmann-La Roche AG
F. HOFFMANN-LA ROCHE AG
F. HOFFMANN-LA ROCHE AG
GENENTECH INC 1 DNA Way South San Francisco California CA
GENENTECH, INC.
HOFFMANN-LA ROCHE
HOFFMANN-LA ROCHE
F. Hoffmann-La Roche AG
HOFFMANN-LA ROCHE ([CH])
GENENTECH, INC.
GENENTECH, INC. ([US])
F. Hoffmann-La Roche AG
F. Hoffmann-La Roche AG
GENENTECH, INC. ([US])
GENENTECH, INC.
GENENTECH, INC.
GENENTECH, INC. ([US])
GENENTECH, INC.
GENENTECH, INC. ([US])
GENENTECH INC.
GENENTECH, INC. ([US])
GENENTECH, INC.
GENENTECH, INC.
GENENTECH, INC. ([US])
GENENTECH, INC. ([US])
GENENTECH, INC.
GENENTECH, INC.
GENENTECH, INC.
F. Hoffmann-La Roche AG
GENENTECH, INC.
GENENTECH, INC. ([US])
HOFFMANN-LA ROCHE ([CH])
GENENTECH INC ([US])
GENENTECH, INC. ([US])
F. Hoffmann-La Roche AG
HOFFMANN LA ROCHE
HOFFMANN LA ROCHE ([CH])
F. HOFFMANN - LA ROCHE AG
F. Hoffmann-La Roche AG
GENENTECH, INC.
F. Hoffmann-La Roche AG
HOFFMANN LA ROCHE ([CH])
HOFFMANN LA ROCHE
GENENTECH, INC. ([US])
F. Hoffmann-La Roche AG
HOFFMANN LA ROCHE ([CH])
HOFFMANN LA ROCHE ([CH])
HOFFMANN LA ROCHE ([CH])
HOFFMANN LA ROCHE ([SE])
F.Hoffmann-La Roche AG
GENENTECH INC ([US])
HOFFMANN LA ROCHE ([CH])
HOFFMANN LA ROCHE
F. HOFFMANN - LA ROCHE AG
F. Hoffmann-La Roche AG
GENENTECH INC ([US])
HOFFMANN LA ROCHE ([CH])
F. Hoffmann-La Roche AG
Priority Details 2008US-61121092 2008-12-092009AU-0333580 2009-12-082009CA-2740806 2009-12-082009CN-80149532 2009-12-082009EP-0764997 2009-12-082009NZ-0628293 2009-12-082009US-12633339 2009-12-082009WO-US67104 2009-12-082012US-13475382 2012-05-182012US-13478421 2012-05-232012US-13478511 2012-05-232012US-13479470 2012-05-242013US-13954796 2013-07-302013US-13964919 2013-08-122013US-14062851 2013-10-242014US-14226349 2014-03-262014US-14303153 2014-06-122014US-14538072 2014-11-112015US-14610593 2015-01-302015US-14825779 2015-08-132015US-14846457 2015-09-042016AU-0203867 2016-06-092016US-15075616 2016-03-212016US-15335278 2016-10-262017EP-0162438 2009-12-082018AU-0203226 2018-05-092018US-15881611 2018-01-262019JP-0071460 2019-04-032020AU-0204593 2020-07-092020KR-7012431 2009-12-082020US-16854707 2020-04-212020US-17108983 2020-12-012021EP-0169871 2009-12-082021JP-0196323 2021-12-022021KR-7015160 2009-12-082021US-17398842 2021-08-102022EP-0180770 2009-12-082022EP-0215991 2009-12-082022KR-7011061 2009-12-082022US-17741919 2022-05-112023EP-0214687 2009-12-082023KR-7015324 2009-12-082023US-18160094 2023-01-262024AU-0200864 2024-02-12
Designated States Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO SE SI SK SM TR
Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO SE SI SK SM TR
Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO SE SI SK SM TR
Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO SE SI SK SM TR
Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO SE SI SK SM TR
Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO SE SI SK SM TR
Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO SE SI SK SM TR
National States: AE AG AL AM AO AT AU AZ BA BB BG BH BR BW BY BZ CA CH CL CN CO CR CU CZ DE DK DM DO DZ EC EE EG ES FI GB GD GE GH GM GT HN HR HU ID IL IN IS JP KE KG KM KN KP KR KZ LA LC LK LR LS LT LU LY MA MD ME MG MK MN MW MX MY MZ NA NG NI NO NZ OM PE PG PH PL PT RO RS RU SC SD SE SG SK SL SM ST SV SY TJ TM TN TR TT TZ UA UG US UZ VC VN ZA ZM ZW
ARIPO: BW GH GM KE LS MW MZ NA SD SL SZ TZ UG ZM ZW
EAPO: AM AZ BY KG KZ MD RU TJ TM
EPO: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LT LU LV MC MK MT NL NO PL PT RO SE SI SK SM TR
OAPI: BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG
   
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