Patent Number US8048904 B2 2011-11-01
 
Process for the preparation of olmesartan medoxomil
The present invention provides a process for the preparation of Olmesartan medoxomil by condensing the ethyl 4-(1-hydroxy-1-methylethyl)-2-propylimidazole-5-carboxylate with 4-[2-(trityl tetrazol-5-yl)phenyl]benzyl bromide to obtain ethyl 4-(1-hydroxy-1-methyl ethyl)-2-propyl-1-{4-[2-(trityl tetrazol-5-yl)phenyl]phenyl}methylimidazole-5-carboxylate and then hydrolyzing ethyl 4-(1-hydroxy-1-methyl ethyl)-2-propyl-1-{4-[2-(trityl tetrazol-5-yl)phenyl]phenyl}methyl imidazole-5-carboxylate to obtain trityl Olmesartan dihydrate followed by reacting trityl Olmesartan dihydrate with 4-chloromethyl-5-methyl-2-oxo-1,3-dioxolene to obtain trityl Olmesartan medoxomil and then deprotecting trityl Olmesartan medoxomil to obtain Olmesartan medoxomil.
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Publication Number Type Publi.Date Links
  US20090281327 A1 2009-11-12
STG: (A1) Application published
AP: 2007US-12305512
  US8048904 B2 2011-11-01
STG: (B2) Granted patent as second publication
AP: 2007US-12305512
PCT  WO2007/148344 A2 2007-12-27
STG: (A2) International application published without international search report
AP: 2007WO-IN00238
PCT  WO2007/148344 A3 2008-04-24
STG: (A3) Later publication of ISR with revised front page
AP: 2007WO-IN00238
First Date of Grant 2011-11-01
Inventor RAMANJANEYULU GORANTLA SEETA
MOHAN BANDARI
RAY PURNA CHANDRA
SETHI MADHURESH KUMAR
RAWAT VIJENDRA SINGH
KRISHNA YERRAMALLA RAJA
LAKSHMINARAYANA VEMULA
SRINIVAS MAMIDI
All applicant/assignee RAMANJANEYULU GORANTLA SEETA
MOHAN BANDARI
RAY PURNA CHANDRA
SETHI MADHURESH KUMAR
RAWAT VIJENDRA SINGH
KRISHNA YERRAMALLA RAJA
LAKSHMINARAYANA VEMULA
SRINIVAS MAMIDI
Matrix Laboratories Ltd. ([IN])
MATRIX LABORATORIES LIMITED ([IN])
MATRIX LABORATORIES LIMITED
Priority Details 2006IN-CH01046 2006-06-192006IN-CH02427 2006-12-272007WO-IN00238 2007-06-15
Designated States National States: AE AG AL AM AT AU AZ BA BB BG BH BR BW BY BZ CA CH CN CO CR CU CZ DE DK DM DO DZ EC EE EG ES FI GB GD GE GH GM GT HN HR HU ID IL IN IS JP KE KG KM KN KP KR KZ LA LC LK LR LS LT LU LY MA MD ME MG MK MN MW MX MY MZ NA NG NI NO NZ OM PG PH PL PT RO RS RU SC SD SE SG SK SL SM SV SY TJ TM TN TR TT TZ UA UG US UZ VC VN ZA ZM ZW
ARIPO: BW GH GM KE LS MW MZ NA SD SL SZ TZ UG ZM ZW
EAPO: AM AZ BY KG KZ MD RU TJ TM
EPO: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LT LU LV MC MT NL PL PT RO SE SI SK TR
OAPI: BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG
   
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